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JianghongHuang, ab JianyiXiong,a LeiYang,a JunZhang,b ShuqingSun cand YujieLiang*d

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* corresponding authors

a room of Orthopedics, Shenzhen second People's Hospital (First Affiliated Hospital of Shenzhen University, wellness Science Center), Shenzhen 518035, China

b Tsinghua university Shenzhen international Graduate School, innovation Leading engineering Doctor, course 9 the 2020, Shenzhen, China

c Tsinghua university Shenzhen worldwide Graduate School, academy of Biomedicine and Health Engineering, Shenzhen, China

d department of Child and Adolescent Psychiatry, Shenzhen Kangning Hospital, Shenzhen Mental health Center, Shenzhen crucial Laboratory because that Psychological health care & Shenzhen academy of psychological Health, Shenzhen, China E-mail: liangyjie

With the advancement of regenerative medicine, organization repair at the molecular, cellular, tissue, and organ level has seen continuous improvements over timeless techniques. Together the main point of tissue repair, seeds cells room widely offered in various fields of regenerative medicine. However, their usage is still linked with problems such as lessened cell survival and also regeneration volume after transplantation, immune rejection, and ethical concerns. Therefore, it is complicated to universally and safely use stem cell financial institutions for regenerative medicine. The paracrine impacts of cells, specifically secretion that exosomes, play vital roles in cabinet communication, immune response, angiogenesis, scar formation, tissue repair, and other biological functions. Exosomes are a kind of nanoscale extracellular vesicle that contain biologically active molecules such together RNA and also proteins; therefore, exosomes can replicate the features of your parental cells. Meanwhile, exosomes have the right to be supplied as nanocarriers to deliver energetic factors or small molecules come promote organization repair. Preclinical researches of exosomes in tissue engineering and regenerative medicine have been carried in the areas of bone/cartilage repair, nerve regeneration, liver and kidney regeneration, skin repair, vascular tissue regeneration, etc. This review introduces exosomes from the elements of biogenesis, composition, identification, and also isolation, and focuses on the development status that scaffold materials for exosome delivery. In addition, we highlight instances of exosome-laden scaffolds because that preclinical applications in tissue repair. We look forward to the vast application prospects of exosome-laden scaffolds.